The Effect of DBD-Non Thermal Plasma on Oxidative Stress and TAC in Patients With HCV Infection

Non-thermal plasma (NTP) is a processing technique that is widely-spread in different biological and medical application which stimulates or inhibits cellular processes through releasing reactive oxygen and nitrogen species (ROS and RNS, respectively) in biological systems. In this study, it was investigated that the impact of NTP on oxidative stress and antioxidant capacity markers, as well as the effect of NTP on the copy number of Hepatitis C virus (HCV RNA). Dielectric barrier discharge (DBD) plasma was used to generate the NTP. The results showed that the exposure of HCV specimen to NTP causes oxidative stress, RNA damage, Protein denaturation, decrease total antioxidant capacity, and decreased copy numbers of HCV RNA in serum samples. In general, these results indicated that the NTP produced by DBD clearly decreases the level of total antioxidant capacity which reflects the total cooperative activities of antioxidants found in the serum.