ASO Visual Abstract: Survival Outcomes and Genetic Characteristics of Resected Pancreatic Acinar Cell Carcinoma
This multi-institutional series of resected pancreatic acinar cell carcinomas demonstrated a median overall survival longer than 70 months (https:// doi.org/ 10. 1245/ s10434-024-16331-4).Mutations within the Homologous Recombination Repair (HRR) pathway were identified in 45% of sequenced tumor specimen, with core HRR mutations in 26%, suggesting opportunities for informed targeted therapeutic options for pancreatic acinar cell carcinoma (pACC).
Authors
- Alice C. Wei (ORCID: https://orcid.org/0000-0002-2505-959X)
- Michael I. D’Angelica (ORCID: https://orcid.org/0000-0002-3731-0534)
- Sabino Zani (ORCID: https://orcid.org/0000-0003-1939-4778)
- Kelly J. Lafaro (ORCID: https://orcid.org/0000-0002-7070-7269)
- Wungki Park (ORCID: https://orcid.org/0000-0002-8006-3102)
- Michael E. Lidsky (ORCID: https://orcid.org/0000-0003-0500-2016)
- Peter J. Allen (ORCID: https://orcid.org/0000-0001-7912-9197)
- Joanne F. Chou (ORCID: https://orcid.org/0000-0002-6866-2022)
- Richard A. Burkhart (ORCID: https://orcid.org/0000-0003-1087-0870)
- William R. Jarnagin (ORCID: https://orcid.org/0000-0002-1635-5768)
- Thomas Clark Howell (ORCID: https://orcid.org/0000-0002-7916-1952)
- William R. Burns (ORCID: https://orcid.org/0000-0002-7634-9730)
- Kevin C. Soares (ORCID: https://orcid.org/0000-0002-0406-017X)
- Vinod P. Balachandran (ORCID: https://orcid.org/0000-0002-2956-223X)
- Shannon N. Radomski (ORCID: https://orcid.org/0000-0002-2923-9096)
- Alex B. Blair (ORCID: https://orcid.org/0000-0002-3297-2299)
- T. Peter Kingham (ORCID: https://orcid.org/0000-0002-3359-3186)
- Eileen Mary O'Reilly (ORCID: https://orcid.org/0000-0002-8076-9199)
- Jing He (ORCID: https://orcid.org/0000-0002-1954-2892)
- Jeffrey A. Drebin (ORCID: https://orcid.org/0000-0003-2312-2062)
- Dan G. Blazer (ORCID: https://orcid.org/0000-0002-7261-9254)
- Lei Zheng (ORCID: https://orcid.org/0000-0003-4163-2541)
- Mengyuan Liu (ORCID: https://orcid.org/0000-0002-6415-9788)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- The Ohio State University Wexner Medical Center (US)
- Johns Hopkins Hospital (US)
- Duke University Hospital (US)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1245/s10434-024-16439-7
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- AstraZeneca
- FibroGen
- Memorial Sloan-Kettering Cancer Center
- Regeneron Pharmaceuticals
- Parker Institute for Cancer Immunotherapy
- Agios Pharmaceuticals
- Break Through Cancer
- Revolution Medicines
- Eisai
- Astellas Pharma
- Ministry of Minority Affairs
- Servier
- Ipsen
- National Institutes of Health
- Genentech
- National Cancer Institute