LncRNA EBLN3P/microRNA-323a-3p/EphA1 axis affects the biological function of hepatocellular carcinoma cells
EBLN3P promotes HCC development by regulating the miR-323a-3p/EphA1 axis. Interfering with EBLN3P effectively restrains proliferation, migration, and invasion of HCC cells by upregulating miR-323a-3p and downregulating EphA1. This mechanism provides new molecular evidence for HCC pathogenesis, suggesting EBLN3P as a potential target in HCC treatment. Future research should explore the interaction between this axis and other tumor-related signaling pathways to support the development of targeted therapeutic strategies.
Authors
- Yuan Cheng (ORCID: https://orcid.org/0000-0002-4476-7241)
- Fakai Qiu
- Pengtao Zhai
- Xudong Mu
- Zhubin Li
- Mei Li (ORCID: https://orcid.org/0000-0001-7516-5676)
- Qunyi Liu
- Qianjin Li
Institutions
- Shaanxi Provincial People's Hospital (CN)
- Yulin University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1007/s12672-025-02902-8
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87