LncRNA EBLN3P/microRNA-323a-3p/EphA1 axis affects the biological function of hepatocellular carcinoma cells

EBLN3P promotes HCC development by regulating the miR-323a-3p/EphA1 axis. Interfering with EBLN3P effectively restrains proliferation, migration, and invasion of HCC cells by upregulating miR-323a-3p and downregulating EphA1. This mechanism provides new molecular evidence for HCC pathogenesis, suggesting EBLN3P as a potential target in HCC treatment. Future research should explore the interaction between this axis and other tumor-related signaling pathways to support the development of targeted therapeutic strategies.

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Publication Details

Journal
Discover Oncology
Published
2025-06-18
DOI
https://doi.org/10.1007/s12672-025-02902-8
Citations
2
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
1.87
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article

LncRNA EBLN3P/microRNA-323a-3p/EphA1 axis affects the biological function of hepatocellular carcinoma cells

Yuan Cheng, Fakai Qiu, Pengtao Zhai, Xudong Mu et al.
2 citations
Discover Oncology
Cancer-related molecular mechanisms research
1.87
article

LncRNA EBLN3P/microRNA-323a-3p/EphA1 axis affects the biological function of hepatocellular carcinoma cells

Yuan Cheng, Fakai Qiu, Pengtao Zhai, Xudong Mu, Zhubin Li, Mei Li, Qunyi Liu, Qianjin Li
article en
2 citations

Abstract

EBLN3P promotes HCC development by regulating the miR-323a-3p/EphA1 axis. Interfering with EBLN3P effectively restrains proliferation, migration, and invasion of HCC cells by upregulating miR-323a-3p and downregulating EphA1. This mechanism provides new molecular evidence for HCC pathogenesis, suggesting EBLN3P as a potential target in HCC treatment. Future research should explore the interaction between this axis and other tumor-related signaling pathways to support the development of targeted therapeutic strategies.

Discover OncologyVol. 16(1)
Shaanxi Provincial People's Hospital (CN), Yulin University (CN)
Openalex Percentile: Top 14%
Cancer-related molecular mechanisms research
1.87
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LncRNA EBLN3P/microRNA-323a-3p/EphA1 axis affects the biological function of hepatocellular carcinoma cells — Yuan Cheng, Fakai Qiu, et al. · Discover Oncology (2025) | TGRS Research Map | TGRS