Cytoskeleton imaging of colorectal and lung cancer spheroids using light sheet microscopy
Our findings proved the power of the proposed LS meso aspheric optics approach to visualize and quantify F-actin in 3D cancer models with a high level of detail. Importantly, our findings also facilitate the assessment of the necrotic area's extent, clearing the path for improved anti-metastatic treatments and more accurate patient prognosis evaluation.
Authors
- Seyed Meraaj Foroughipour
- Klaus Becker (ORCID: https://orcid.org/0000-0002-2406-0476)
- Massih Foroughipour (ORCID: https://orcid.org/0000-0001-6062-2985)
- Heinz D. Wanzenboeck (ORCID: https://orcid.org/0000-0002-0893-273X)
- Saiedeh Saghafi (ORCID: https://orcid.org/0000-0002-7598-541X)
- Lukas M. Weber (ORCID: https://orcid.org/0000-0002-3282-1730)
- Sonia Prado‐Lòpez (ORCID: https://orcid.org/0000-0003-0918-7919)
- Nika Sarem
Institutions
- TU Wien (AT)
- Medical University of Graz (AT)
Publication Details
- Journal
- BJC Reports
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1038/s44276-025-00144-3
- Citations
- 1
- Primary Topic
- Advanced Fluorescence Microscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Vienna Science and Technology Fund
- Technische Universität Wien
- Österreichische Forschungsförderungsgesellschaft
- Technische Universität Wien Bibliothek