Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents
Bergapten, a natural product from <i>Zanthoxylum bungeanum</i> Maxim., exhibits anticancer, antibacterial, anti-inflammatory, and hypolipidemic effects. A derivative, FSG-Y5 showed potent activity against pancreatic cancer cells PANC-1 (IC<sub>50</sub> = 2.31 ± 0.25 µM) and CFPAC-1 (IC<sub>50</sub> = 4.41 ± 0.47 µM), inhibiting their survival, migration, and invasion while inducing apoptosis <i>via</i> Bax and Cleaved caspase-3 regulation. FSG-Y5 also suppressed pancreatic cancer organoids and zebrafish tumor growth in a concentration and time-dependent manner. These findings highlight bergapten derivatives as promising anticancer candidates, with FSG-Y5 as a potential anti-pancreatic cancer agent for further study.
Authors
- Jun‐Li Yang (ORCID: https://orcid.org/0000-0001-7199-0214)
- Xingrong Wang (ORCID: https://orcid.org/0000-0001-9838-1902)
- Jia-Rong Liu
- Ying Yue (ORCID: https://orcid.org/0000-0002-7999-0363)
- Nan Wang (ORCID: https://orcid.org/0000-0003-4630-5216)
- Junyi Ma
Institutions
- Minzu University of China (CN)
- Chinese Academy of Sciences (CN)
- Science North (CA)
- Lanzhou Institute of Chemical Physics (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Northwest Normal University (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1080/10286020.2025.2514692
- Citations
- 1
- Primary Topic
- Synthesis and Biological Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China