Fluorescence-Guided Surgery for Assessing Margins in Head and Neck Cancer

Currently, there are several clinical trials investigating FGS to improve margin clearance in HNSCC, with many fluorescent agents already approved for use in other cancer types. As additional agents are brought into clinical use, it will be critical to understand how this technique will or will not improve oncological management in our patients. To address this important point, we present 2 key areas where surgeons will consider use of these FGS: to assess the peripheral mucosal margin and the deep surface of the tumor. We outline how in vivo and ex vivo fluorescence can be used for this purpose. We summarize data from multiple sources to explain how FGS is most likely to help with deep margin clearance.

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Publication Details

Journal
JAMA Surgery
Published
2025-06-18
DOI
https://doi.org/10.1001/jamasurg.2025.1815
Citations
3
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
5.54
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article

Fluorescence-Guided Surgery for Assessing Margins in Head and Neck Cancer

Baran D. Sumer, Robert J. Sinard, Jennifer H. Choe, Michael C. Topf et al.
3 citations
JAMA Surgery
Head and Neck Cancer Studies
5.54
article

Fluorescence-Guided Surgery for Assessing Margins in Head and Neck Cancer

Baran D. Sumer, Robert J. Sinard, Jennifer H. Choe, Michael C. Topf, Sarah L. Rohde, Swarnalatha Gowrishankar, Alexander Langerman, Hidenori Tanaka, Stan van Keulen, Anne Marie Mattingly, Mark A. Varvares, Kyle Mannion, Eben Lloyd Rosenthal
article en
3 citations

Abstract

Currently, there are several clinical trials investigating FGS to improve margin clearance in HNSCC, with many fluorescent agents already approved for use in other cancer types. As additional agents are brought into clinical use, it will be critical to understand how this technique will or will not improve oncological management in our patients. To address this important point, we present 2 key areas where surgeons will consider use of these FGS: to assess the peripheral mucosal margin and the deep surface of the tumor. We outline how in vivo and ex vivo fluorescence can be used for this purpose. We summarize data from multiple sources to explain how FGS is most likely to help with deep margin clearance.

JAMA SurgeryVol. 160(9)
Massachusetts Eye and Ear Infirmary (US), Southwestern Medical Center (US), Rijnstate Hospital (NL), Southwestern Medical Center (US), The University of Texas Southwestern Medical Center (US), Vanderbilt University Medical Center (US)
Good health and well-being
Openalex Percentile: Top 4%
Head and Neck Cancer Studies
5.54
DOISourceOpenAlex
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