Framework for Brain-Derived Dimensions of Psychopathology
In this study, the identification of symptom groups of mental illness robustly defined by precisely characterized brain mechanisms enabled the characterization of dimensions of psychopathology based on quantifiable neurobiological measures.
Authors
- Andreas Heinz (ORCID: https://orcid.org/0000-0001-5405-9065)
- Sylvane Desrivières (ORCID: https://orcid.org/0000-0002-9120-7060)
- Bernhard Spanlang (ORCID: https://orcid.org/0000-0002-9659-635X)
- Lars Tjelta Westlye (ORCID: https://orcid.org/0000-0001-8644-956X)
- Ulrike Schmidt (ORCID: https://orcid.org/0000-0003-1335-1937)
- Kerstin Schepanski (ORCID: https://orcid.org/0000-0002-1027-6786)
- Andreas Meyer‐Lindenberg (ORCID: https://orcid.org/0000-0001-5619-1123)
- Antoine Bernas (ORCID: https://orcid.org/0000-0002-2006-4891)
- Rüdiger Brühl (ORCID: https://orcid.org/0000-0003-0111-5996)
- Tomáš Paus (ORCID: https://orcid.org/0000-0003-1495-9338)
- Nicholas Clinton (ORCID: https://orcid.org/0000-0002-1112-1006)
- Ragnhild Eek Brandlistuen (ORCID: https://orcid.org/0000-0001-8054-0960)
- Myrto Patraskaki
- Mira Tschorn (ORCID: https://orcid.org/0000-0002-9128-3987)
- Esther Hitchen
- Yanqing Zhang (ORCID: https://orcid.org/0000-0002-2785-938X)
- Jiacan Yuan (ORCID: https://orcid.org/0000-0003-3847-4490)
- Tobias Banaschewski (ORCID: https://orcid.org/0000-0003-4595-1144)
- Jaime Gallego (ORCID: https://orcid.org/0000-0003-3332-619X)
- Carina M. Mathey (ORCID: https://orcid.org/0009-0005-3484-3051)
- Emanuel Schwarz (ORCID: https://orcid.org/0000-0002-0261-5063)
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
- Rikka Kjelkenes (ORCID: https://orcid.org/0000-0003-4793-4428)
- Nina Christmann (ORCID: https://orcid.org/0000-0002-4089-3830)
- Per Hoffmann (ORCID: https://orcid.org/0000-0002-6573-983X)
- Heike Tost (ORCID: https://orcid.org/0000-0002-7339-7569)
- Helga Ask (ORCID: https://orcid.org/0000-0003-0149-5319)
- Marie‐Laure Paillère Martinot (ORCID: https://orcid.org/0000-0002-0452-2450)
- Xinyang Yu (ORCID: https://orcid.org/0000-0001-8026-4839)
- Arun L.W. Bokde (ORCID: https://orcid.org/0000-0003-0114-4914)
- Xiao Chang (ORCID: https://orcid.org/0000-0002-0230-0416)
- Vince D. Calhoun (ORCID: https://orcid.org/0000-0001-9058-0747)
- Emin Serin (ORCID: https://orcid.org/0000-0002-3570-3027)
- Tamara Schikowski (ORCID: https://orcid.org/0000-0002-4559-9374)
- Sven Twardziok (ORCID: https://orcid.org/0000-0002-0326-5704)
- Francisco José Eiroá‐Orosa (ORCID: https://orcid.org/0000-0002-4163-6545)
- Paul Renner (ORCID: https://orcid.org/0009-0002-4472-5700)
- Nathalie Holz (ORCID: https://orcid.org/0000-0002-6225-9267)
- Bernd Carsten Stahl (ORCID: https://orcid.org/0000-0002-4058-4456)
- Jean-Charles Roy (ORCID: https://orcid.org/0000-0003-0686-4099)
- Roland Eils (ORCID: https://orcid.org/0000-0002-0034-4036)
- Herta Flor (ORCID: https://orcid.org/0000-0003-4809-5398)
- Viktor Jirsa (ORCID: https://orcid.org/0000-0002-8251-8860)
- Sarah Jane Böttger (ORCID: https://orcid.org/0000-0002-4994-4534)
- Antoine Grigis (ORCID: https://orcid.org/0000-0001-7984-3710)
- Michael A. Rapp (ORCID: https://orcid.org/0000-0003-0106-966X)
- Andreas J. Forstner (ORCID: https://orcid.org/0000-0002-1876-6368)
- Kofoworola Agunbiade (ORCID: https://orcid.org/0000-0002-6355-417X)
- Rieke Aden
- Julia Sinclair (ORCID: https://orcid.org/0000-0002-1905-2025)
- André F. Marquand (ORCID: https://orcid.org/0000-0001-5903-203X)
- Spase Petkoski (ORCID: https://orcid.org/0000-0003-4540-6293)
- Stefanie Heilmann‐Heimbach (ORCID: https://orcid.org/0000-0003-1057-465X)
- Peter Sommer (ORCID: https://orcid.org/0000-0001-9241-5710)
- Tianye Jia (ORCID: https://orcid.org/0000-0001-5399-2953)
- Allan H. Young (ORCID: https://orcid.org/0000-0003-2291-6952)
- Jeanne Winterer (ORCID: https://orcid.org/0000-0002-6041-8615)
- Luise Poustka (ORCID: https://orcid.org/0000-0002-7738-4394)
- Hervé Lemaître (ORCID: https://orcid.org/0000-0002-5952-076X)
- Tristram A. Lett (ORCID: https://orcid.org/0000-0002-0731-9626)
- Michael N. Smolka (ORCID: https://orcid.org/0000-0001-5398-5569)
- Dimitri Papadopoulos Orfanos (ORCID: https://orcid.org/0000-0002-1242-8990)
- Markus Ralser (ORCID: https://orcid.org/0000-0001-9535-7413)
- Mel Slater (ORCID: https://orcid.org/0000-0002-6223-0050)
- Sara Fernández‐Cabello (ORCID: https://orcid.org/0000-0002-2589-8449)
- Johannes Wilbertz (ORCID: https://orcid.org/0000-0002-0002-6847)
- Frauke Nees (ORCID: https://orcid.org/0000-0002-7796-8234)
- Guillem Feixas (ORCID: https://orcid.org/0000-0002-6288-6009)
- George Ogoh (ORCID: https://orcid.org/0000-0002-5287-408X)
- Lea Waller (ORCID: https://orcid.org/0000-0002-3239-6957)
- Elli Polemiti (ORCID: https://orcid.org/0000-0001-9526-3468)
- Trevor William Robbins (ORCID: https://orcid.org/0000-0003-0642-5977)
- Isabelle Claus (ORCID: https://orcid.org/0009-0003-5739-2615)
- Eric Artiges A (ORCID: https://orcid.org/0000-0003-4461-7646)
- Argyris Stringaris (ORCID: https://orcid.org/0000-0002-6264-8377)
- Zuo Zhang (ORCID: https://orcid.org/0000-0002-6752-3434)
- Karen M. Schmitt (ORCID: https://orcid.org/0000-0003-3646-6323)
- Vanessa Köhler
- Markus M. Nöthen (ORCID: https://orcid.org/0000-0002-8770-2464)
- Maja Neidhart
- Gaia Novarino
- Charlie Pearmund
- Sören Hese
- Ulrike Taron
- Di Chen (ORCID: https://orcid.org/0000-0002-6983-1641)
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
- Yuning Zhang (ORCID: https://orcid.org/0000-0003-2225-6368)
- Yuzhu Li (ORCID: https://orcid.org/0000-0003-4231-6487)
- Dennis van der Meer (ORCID: https://orcid.org/0000-0002-9473-4536)
- Hugh Garavan
- Henrik Walter
- Karina Janson
- Hedi Kebir
- Nilakshi Vaidya
- Robert Whelan
- Jean-Luc Martinot
- Penny Gowland
- Marcel Jentsch
- Ameli Schwalber
- Abigail Miller
- Yunman Xia (ORCID: https://orcid.org/0000-0003-2593-9252)
- Tatjana Schütz
- Álvaro Pastor
- Anastasios Athanasiadis (ORCID: https://orcid.org/0009-0000-4613-0941)
- Yuxiang Dai (ORCID: https://orcid.org/0000-0003-2479-8996)
- Beke Seefried
Institutions
- University of Vermont (US)
- École Normale Supérieure Paris-Saclay (FR)
- National Health Service (GB)
- Physikalisch-Technische Bundesanstalt (DE)
- University of Nottingham (GB)
- Radboud University Nijmegen (NL)
- Université de Bordeaux (FR)
- Inserm (FR)
- University of Mannheim (DE)
- King's College London (GB)
- University of Toronto (CA)
- South London and Maudsley NHS Foundation Trust (GB)
- Trinity College Dublin (IE)
- Heidelberg University (DE)
- University of Cambridge (GB)
- Fudan University (CN)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- University Hospital Heidelberg (DE)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Radboud University Medical Center (NL)
- Christian-Albrechts-Universität zu Kiel (DE)
- Humboldt-Universität zu Berlin (DE)
- Sorbonne Université (FR)
- Institut des Maladies Neurodégénératives (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Central Institute of Mental Health (DE)
- Pitié-Salpêtrière Hospital (FR)
- Laboratoire de Biologie et Pharmacologie Appliquée (FR)
- Huashan Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- University of Southampton (GB)
- University College London (GB)
- Université de Montréal (CA)
- Freie Universität Berlin (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1001/jamapsychiatry.2025.1246
- Citations
- 4
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 8.47
Funders
- University of Southampton
- King's College London
- University College London
- Trinity College Dublin
- Institut National de la Santé et de la Recherche Médicale
- Technische Universität Dresden
- University of Toronto
- Centre National de la Recherche Scientifique
- Humboldt-Universität zu Berlin
- Université de Bordeaux
- Université Paris-Saclay
- Freie Universität Berlin
- Assistance publique-Hôpitaux de Paris
- Centre hospitalier universitaire Sainte-Justine
- Berlin Institute of Health
- Sorbonne Université
- Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Department of Psychiatry, University of Toronto