Uveal Melanoma and the Lynch Syndrome Tumor Spectrum

This prospective germline study on patients with UM provided evidence supporting the notion that MMR germline alterations are enriched among patients with UM and may contribute to oncogenesis of UM, and that UM may therefore be a rare tumor manifestation of Lynch syndrome.

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Publication Details

Journal
JAMA Ophthalmology
Published
2025-06-18
DOI
https://doi.org/10.1001/jamaophthalmol.2025.1779
Citations
2
Primary Topic
Ocular Oncology and Treatments
Type
article
Field-Weighted Citation Impact
3.41
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article

Uveal Melanoma and the Lynch Syndrome Tumor Spectrum

Livia Lumbroso‐Le Rouic, Sophie Piperno‐Neumann, Victor Renault, Denis Malaise et al.
2 citations
JAMA Ophthalmology
Ocular Oncology and Treatments
3.41
article

Uveal Melanoma and the Lynch Syndrome Tumor Spectrum

Livia Lumbroso‐Le Rouic, Sophie Piperno‐Neumann, Victor Renault, Denis Malaise, Nathalie Cassoux, Fatoumata Simaga, André Bortolini Silveira, Kevin Merchadou, Marc‐Henri Stern, Chrystelle Colas, Alexandre Matet, Antoine De Pauw, Alexandre Houy, Manuel Rodrigues, Julien Masliah‐Planchon, Sophie El Zein, Thibault Verrier, Juliette Sauge, Bruno Buecher, Anne Vincent-Salomon, Dominique Stoppa-Lyonnet, Anaïs Le Ven, Marie-Charlotte Villy, Lisa Golmard, Catherine Dubois d’Enghien, Marion Gauthier‐Villars, Marine Le Mentec, Mathilde Warcoin
article en
2 citations

Abstract

This prospective germline study on patients with UM provided evidence supporting the notion that MMR germline alterations are enriched among patients with UM and may contribute to oncogenesis of UM, and that UM may therefore be a rare tumor manifestation of Lynch syndrome.

JAMA OphthalmologyVol. 143(8)
Inserm (FR), Université Paris Cité (FR), Institut Curie (FR)
Openalex Percentile: Top 8%
Ocular Oncology and Treatments
3.41
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