Assessing causal associations between TNF-related apoptosis-inducing ligand, vascular endothelial growth factor and colon cancer: a Mendelian-randomization study
There was a inverse association between genetic variants in TRAIL levels and colon cancer risk, but a positive association between genetic variants in VEGF levels and colon cancer risk. Further research is needed to explore the mechanisms behind this putative causal relationship.
Authors
- Jingyu Wu
- Xiaoyu Shi (ORCID: https://orcid.org/0009-0009-4955-5836)
- Xiaofei Zheng (ORCID: https://orcid.org/0000-0001-7502-6131)
- Fangfang Zhang (ORCID: https://orcid.org/0000-0003-2659-2561)
- Chaoyang Zhang (ORCID: https://orcid.org/0000-0001-6816-3840)
- Jian Chen (ORCID: https://orcid.org/0000-0002-3909-6615)
- Chu Zhang (ORCID: https://orcid.org/0000-0003-2358-4953)
- Bei Qian (ORCID: https://orcid.org/0000-0003-1524-7340)
- Chunhui Cao
Institutions
- Wannan Medical College (CN)
- Chizhou University (CN)
- Zhejiang Cancer Hospital (CN)
- Wuhan Union Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Union Hospital (CN)
- Hefei First People's Hospital (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1007/s12672-025-02864-x
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project
- Medical Science and Technology Project of Zhejiang Province
- Science and Technology Program of Zhejiang Province