Comparative analysis of morphometric and histological characteristics of HPV-associated and HPV-independent vulvar squamous cell carcinoma
A smaller cell area and a nuclear-cytoplasmic ratio shift toward the nucleus characterize HPV-associated carcinomas. With HPV-independent carcinogenesis, tumor cells more often retain the ability to differentiate and mature the epithelium. Immunohistochemical determination of p16 and p53 expression is a more accurate method for determining the HPV status of vulvar carcinoma.
Authors
- M.I. Pakharukova (ORCID: https://orcid.org/0000-0001-6019-3463)
- B. G. Yushkov
Institutions
- Institute of Immunology and Physiology (RU)
Publication Details
- Journal
- Russian Journal of Archive of Pathology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.17116/patol20258703126
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00