Timing and Predictors for Vonoprazan Dose Escalation in Refractory Gastroesophageal Reflux Disease: A Long-Term Observational Study
The incidence of refractory GERD requiring VPZ dose escalation is relatively low. Epigastric pain prior to VPZ initiation independently predicts the need for dose escalation. VPZ dose escalation effectively improves GERD symptoms.
Authors
- Hirotsugu Sakamoto (ORCID: https://orcid.org/0000-0002-2458-1693)
- Satoshi Shinozaki (ORCID: https://orcid.org/0000-0001-6935-4470)
- Tomonori Yano (ORCID: https://orcid.org/0000-0002-0160-432X)
- Nikolaos Lazaridis (ORCID: https://orcid.org/0000-0001-6674-4406)
- Hironori Yamamoto (ORCID: https://orcid.org/0000-0002-3601-1153)
- Hiroyuki Osawa (ORCID: https://orcid.org/0000-0002-1479-0475)
Institutions
- Jichi Medical University (JP)
- The Royal Free Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Digestion
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1159/000546992
- Citations
- 1
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.81