Remdesivir Treatment Outcomes of Subacute Sclerosing Panencephalitis Presenting with Macular Necrotizing Retinitis: A Case Report
While remdesivir failed to arrest measles-associated macular necrosis, it may have prevented disease progression in the contralateral eye and in the CNS. To our knowledge, this is the first case of measles-associated necrotizing retinitis that was confirmed by a positive aqueous PCR. In the absence of an established treatment, vaccination remains the most effective modality. Further investigation of remdesivir as a potential treatment of SSPE is required.
Authors
- Tarek Keadan
- Dana G. Wolf (ORCID: https://orcid.org/0000-0001-5507-4160)
- Dana Ekstein (ORCID: https://orcid.org/0000-0002-3860-6054)
- Esther Oiknine‐Djian (ORCID: https://orcid.org/0000-0001-8105-3734)
- Radgonde Amer (ORCID: https://orcid.org/0000-0002-5730-4254)
- Tamar Fisher-Negev
- Hadas Mechoulam
- Aseel Gebara
- Mohammed Homeidat
Institutions
- Hebrew University of Jerusalem (IL)
- Hadassah Medical Center (IL)
- University Medical Center (US)
Publication Details
- Journal
- Ocular Immunology and Inflammation
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1080/09273948.2025.2521370
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00