CHEK1 variant is a risk factor for premature ovarian insufficiency by mis- regulating metabolism and inflammation-related genes
CHEK1 may be involved in ovarian aging and the A26G variant may increase susceptibility to POI.
Authors
- Lin Li (ORCID: https://orcid.org/0000-0002-3972-735X)
- Yali Fan
- Jianying Guo (ORCID: https://orcid.org/0009-0002-4513-4670)
- Meng Fu (ORCID: https://orcid.org/0000-0002-8867-0951)
- Zifan Song
Institutions
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Peking University Third Hospital (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1186/s40246-025-00774-1
- Citations
- 2
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- National Natural Science Foundation of China
- Capital Medical University
- Peking University
- Peking University Third Hospital
- National Key Research and Development Program of China