<i>XPO1</i> <i>R749Q</i> Mutations Co-occur with <i>POLE</i> Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance
XPO1 R749Q is a recurrent mutation in cancer that is associated with POLE mutations and corresponds to topoisomerase I inhibitor resistance, which can be overcome by addition of the XPO1 inhibitor selinexor.
Authors
- Phil Walker
- Tulasigeri M. Totiger (ORCID: https://orcid.org/0000-0002-4262-4458)
- Ryan Q. Notti (ORCID: https://orcid.org/0000-0002-9197-6134)
- Wannasiri Chiraphapphaiboon (ORCID: https://orcid.org/0000-0002-4244-4895)
- Daniel Bilbao (ORCID: https://orcid.org/0000-0003-1630-8811)
- Sana Chaudhry (ORCID: https://orcid.org/0000-0003-1559-0974)
- Andrew Elliott (ORCID: https://orcid.org/0000-0001-8494-8031)
- Maurizio Affer (ORCID: https://orcid.org/0000-0002-7247-6273)
- Monika Chojnacka (ORCID: https://orcid.org/0000-0001-7176-6108)
- Skye Montoya (ORCID: https://orcid.org/0000-0002-2094-6923)
- Efe Karaca (ORCID: https://orcid.org/0000-0003-4109-6013)
- Jenna Zabroski
- Jacob Jahn (ORCID: https://orcid.org/0000-0003-0745-7049)
- Emil Lou (ORCID: https://orcid.org/0000-0002-1607-1386)
- Christopher Armstrong (ORCID: https://orcid.org/0000-0002-9236-472X)
- Jumana Afaghani (ORCID: https://orcid.org/0000-0001-7943-1898)
- Hai Dang Nguyen (ORCID: https://orcid.org/0000-0002-4200-8778)
- José Antonio Rodríguez (ORCID: https://orcid.org/0000-0002-2823-3733)
- Yasmine Baca (ORCID: https://orcid.org/0000-0003-2130-0611)
- Wafik S. El‐Deiry (ORCID: https://orcid.org/0000-0002-9577-8266)
- Gabriel Gaidosh (ORCID: https://orcid.org/0000-0002-7582-9652)
- Rajesh K. Soni (ORCID: https://orcid.org/0000-0002-4556-4358)
- Justin Taylor (ORCID: https://orcid.org/0000-0003-4407-6325)
- M. H. Lewis (ORCID: https://orcid.org/0009-0008-9405-3563)
- Alyssa Maye
- Paul M. Kavanaugh
Institutions
- University of Minnesota (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Miami (US)
- University of the Basque Country (ES)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- University of Minnesota System (US)
- University of Miami Health System (US)
- Phoenix (United States) (US)
- University Gastroenterology (US)
- Caris Life Sciences (United States) (US)
- Sylvester Comprehensive Cancer Center (US)
- Columbia University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3112
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00