Effect of retinoic acid treatment on the retinoic acid signaling pathway in a human siRNA-based aniridia limbal epithelial cell model, in vitro
Our results reveal a reduced proliferation rate in PAX6 knockdown LECs, along with a less pronounced downregulation of proliferation in response to increased RA concentration. Additionally, the study highlights altered expression of key regulators in the RA signaling pathway, influenced by both PAX6 activity and RA treatment. These findings suggest a potential disruption in RA-mediated cellular regulation in PAX6-deficient LECs.
Authors
- Tanja Stachon (ORCID: https://orcid.org/0000-0001-7009-7125)
- Zhen Li (ORCID: https://orcid.org/0000-0001-5491-2169)
- Samrat T. Kundu (ORCID: https://orcid.org/0000-0002-0117-6986)
- Maryam Amini (ORCID: https://orcid.org/0009-0000-3118-9959)
- Shuailin Li
- Shweta Suiwal (ORCID: https://orcid.org/0000-0002-1230-1279)
- Nóra Szentmáry (ORCID: https://orcid.org/0000-0001-8019-1481)
- Fabian Norbert Fries (ORCID: https://orcid.org/0000-0002-8526-4712)
- Shanhe Liu (ORCID: https://orcid.org/0000-0001-8096-4771)
- Shao‐Lun Hsu (ORCID: https://orcid.org/0000-0001-5235-5039)
- Berthold Seitz (ORCID: https://orcid.org/0000-0001-9701-8204)
Institutions
- Saarland University (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1371/journal.pone.0324946
- Citations
- 2
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Dr. Rolf M. Schwiete Stiftung