A genome-wide SNP-SNP interaction analysis exploring novel interacting loci associated with the risk of recurrence in colorectal cancer
We present the results of the first genome-wide SNP-SNP interaction analysis in colorectal cancer outcomes. While no SNP-SNP interaction remained significant after correction for multiple testing, our methodology emphasizes the additional knowledge that can be obtained using interaction analyses while studying prognostic markers.
Authors
- Megan E. Carey (ORCID: https://orcid.org/0000-0002-7797-9080)
- Yildiz E. Yilmaz (ORCID: https://orcid.org/0000-0003-1784-8764)
- Sevtap Savas (ORCID: https://orcid.org/0000-0002-7324-938X)
- Aaron A. Curtis
- Yajun Yu (ORCID: https://orcid.org/0000-0001-5677-1320)
Institutions
- Memorial University of Newfoundland (CA)
- Southwest Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1371/journal.pone.0321967
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Faculty of Medicine, Memorial University of Newfoundland