Bhatt–Hauser Oxidation: A Site-Selective Late-Stage Benzylic C–H Oxidation

Abstract This account provides an overview of the copper-catalyzed, K2S2O8-mediated regioselective advanced-stage benzylic C–H oxidation, a process we have named as the Bhatt–Hauser oxidation. Its impact as a synthetic method, especially in the context of the total synthesis of natural products, is presented. 1 Introduction 2 The Bhatt–Hauser Oxidation 3 Mechanism of the Bhatt–Hauser Oxidation 4 Modifications of the Bhatt–Hauser Oxidation 5 Synthesis of Formylanthraquinones and an Unprecedented Fragmentation 6 General Applications 7 Applications in the Total Synthesis of Natural Products: Advanced-Stage Oxidation 8 Conclusion