Ginsenoside Rd alleviates LPS-induced neuroinflammation and depressive-like behaviors via regulating TLR4-PI3K-NF-κB-JMJD3 signaling
Our research suggests that Rd exerts antidepressant-like effects by alleviating neuroinflammation and enhancing spinogenesis, which may be associated with the modulation of the TLR4-PI3K-NF-κB-JMJD3 signaling pathway.
Authors
- Bingjin Li (ORCID: https://orcid.org/0000-0002-2612-4285)
- Xu Han (ORCID: https://orcid.org/0000-0001-7838-927X)
- Runxin Li
- Ranji Cui (ORCID: https://orcid.org/0000-0002-1129-3772)
- Jingjing Piao
- Zihui Geng
- Hongyu Chen (ORCID: https://orcid.org/0000-0002-5325-9249)
Institutions
- Jilin University (CN)
- Jilin Province Development and Reform Commission (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.intimp.2025.115071
- Citations
- 4
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- Jilin Province Development and Reform Commission
- National Natural Science Foundation of China
- People's Government of Jilin Province