Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury
These results highlight the importance of P2X7 receptors in the acute phase of TBI and present ITH15004 as a promising pharmacological tool to counteract P2X7 receptor-dependent neuroinflammation in vivo.
Authors
- Alexis Palpán Flores (ORCID: https://orcid.org/0000-0003-2537-6955)
- Eva Ramos (ORCID: https://orcid.org/0000-0001-5791-0687)
- Francesco Calzaferri (ORCID: https://orcid.org/0000-0002-4781-2925)
- Javier Rodríguez de Cía (ORCID: https://orcid.org/0000-0002-6389-9741)
- Alejandro Romero (ORCID: https://orcid.org/0000-0001-5483-4973)
- Celine Decouty‐Pérez (ORCID: https://orcid.org/0000-0001-9970-9260)
- Inés Valencia (ORCID: https://orcid.org/0000-0002-6741-8554)
- Javier Giner‐García
- Javier Egea (ORCID: https://orcid.org/0000-0003-4704-3019)
- Ana Belén López-Rodríguez (ORCID: https://orcid.org/0000-0002-0747-7966)
- Cristóbal de los Rı́os (ORCID: https://orcid.org/0000-0002-6456-7589)
- María Álvarez‐Rubal
- Víctor Rodríguez‐Domínguez
- Borja Jesús Hernández-García (ORCID: https://orcid.org/0000-0002-0477-595X)
- Andrea Pastor‐Martínez
Institutions
- Universidad Complutense de Madrid (ES)
- Universidad Rey Juan Carlos (ES)
- Hospital Universitario La Paz (ES)
- Hospital Universitario Santa Cristina (ES)
- Dublin City University (IE)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1111/bph.70108
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00