Mitochondrial heteroplasmy-phenotype correlation and response to glucose lowering therapy in subjects with m.3243A>G mutations
β-cell dysfunction and insulin resistance contribute to mitochondrial diabetes development. 65 % of subjects required insulin to improve glycaemic control. Early insulin initiation may be necessary to improve glycaemic control in the long term.
Authors
- Claire Gavin (ORCID: https://orcid.org/0000-0001-5326-8623)
- Marie Burke
- C J McCarrick
- Jurcău Ioana (ORCID: https://orcid.org/0000-0002-5355-8396)
- James J. O’Byrne (ORCID: https://orcid.org/0000-0003-3162-2411)
- Charles E. Mangan
- Nicholas Ng (ORCID: https://orcid.org/0000-0003-0076-672X)
- Maria M. Byrne (ORCID: https://orcid.org/0000-0002-9394-8698)
- Begoña Sánchez-Lechuga (ORCID: https://orcid.org/0000-0002-4352-9655)
- R O’Byrne
Institutions
- University College Dublin (IE)
- Trinity College Dublin (IE)
- Mater Misericordiae University Hospital (IE)
- Mater Private Hospital (AU)
Publication Details
- Journal
- Diabetes & Metabolism
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.diabet.2025.101678
- Citations
- 3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Sanofi
- Health Research Board
- Novo Nordisk