Synthesis, Characterization and Studying Biological Activity of New Schiff Base Compounds Derived from “N-[(4-hydroxy-3-methoxyphenyl) methyl]-8-methyl-(E)-6-nonenamide”

This research includes synthesizing new bis-Schiff bases linked to“N-[(4-hydroxy-3-methoxyphenyl) methyl]-8-methyl-(E)-6-nonenamide” derivatives. This work involved ring opening of phathalic anhydride by hydroxyl groups in “N-[(4-hydroxy-3-methoxyphenyl) methyl]-8-methyl-(E)-6-nonenamide” then, they were reacted with thiourea to synthesize Schiff bases by the reaction of different aldehydes. The first step involved the condensation reaction between “N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-(E)-6-nonenamide” (H) and phthalic anhydride to produce(H1). In the second step, compound H1 was reacted with one mol of thiourea to produce maliamic compound (H2). The third step involved the preparing of Schiff bases derivatives, by the reaction of (H2) with different aldehyde to produce compounds (H3 and H4). These compounds were characterized depending on their FT-IR, 1H-NMR, and the biological study. The newly synthesized target compounds are expected to be very active biologically since their molecules are essential components of two active groups (imine and amide).