Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels
Enhanced glutamatergic transmission by chronic administration of therapeutically relevant concentrations of clozapine involves increased L-BAIBA signalling, which activates Src signalling via III-mGluR agonistic action, without affecting pannexin1 expression. Activation of pannexin1-hemichannel activity induced by Src signalling and III-mGluR may play an important role in the effectiveness of clozapine in TRS.
Authors
- Motohiro Okada (ORCID: https://orcid.org/0000-0002-9025-2548)
- Eishi Motomura (ORCID: https://orcid.org/0000-0003-3013-9284)
- Ruri Okubo (ORCID: https://orcid.org/0009-0009-9842-8702)
Institutions
- Mie University (JP)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1111/bph.70112
- Citations
- 2
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- Japan Society for the Promotion of Science