The clinicopathologic features of fulminant myocarditis
To date, this largest cohort of histochemical analyses of FM, based on endomyocardial biopsy samples, has revealed dominant infiltration of innate immune cells in the early stage, followed by lymphocytes. This finding suggests that the activation of innate immunity is the initial mechanism triggering the cytokine storm in FM. The results also support the beneficial effects of immunomodulatory therapy using glucocorticoids and immunoglobulins rather than immunosuppression by promoting M2 macrophage polarization. This study was registered at https://clinicaltrials.gov/study/NCT03268642.
Authors
- Guanglin Cui (ORCID: https://orcid.org/0000-0001-7408-4751)
- Luyun Wang (ORCID: https://orcid.org/0009-0003-7975-2693)
- Kun Miao (ORCID: https://orcid.org/0000-0001-6567-3650)
- Jiali Nie (ORCID: https://orcid.org/0000-0003-4568-5958)
- Huihui Li (ORCID: https://orcid.org/0000-0003-0511-1693)
- Chunxia Zhao (ORCID: https://orcid.org/0000-0001-6134-4251)
- Jiangang Jiang (ORCID: https://orcid.org/0000-0002-8606-6291)
- Daowen Wang (ORCID: https://orcid.org/0000-0002-6230-8735)
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.jare.2025.06.040
- Citations
- 2
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Natural Science Foundation of China