Dietary n-3 polyunsaturated fatty acids intervention ameliorates cognitive dysfunction in db/db mice by mitigating cortical insulin resistance, mitochondrial dysfunction, and energy metabolism impairment
n-3 PUFA facilitated the recovery of cognitive function in T2DM mice by regulating cortical mitochondrial energy metabolism and enhancing the glutamate-glutamine cycle.
Authors
- Xiaojun Ma (ORCID: https://orcid.org/0000-0002-7353-5474)
- Shaobo Zhou (ORCID: https://orcid.org/0000-0001-5214-2973)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-1827-8137)
- Yü Liu (ORCID: https://orcid.org/0000-0003-2211-3535)
- Jingjing Xu (ORCID: https://orcid.org/0000-0002-5852-4101)
- Xinjing Guo (ORCID: https://orcid.org/0000-0002-6812-9332)
- Xiuwen Ren
- Xixiang Wang (ORCID: https://orcid.org/0000-0002-3058-951X)
- Ying Wang (ORCID: https://orcid.org/0009-0008-3662-2692)
- Lu Liu (ORCID: https://orcid.org/0000-0003-4865-1673)
Institutions
- University of Nebraska–Lincoln (US)
- Capital Medical University (CN)
- Suzhou Municipal Hospital (CN)
- Beijing YouAn Hospital (CN)
- University of Greenwich (GB)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.jare.2025.06.044
- Citations
- 4
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 4.48