Medulla oblongata dominated synaptic density network degeneration in amyotrophic lateral sclerosis
These findings suggest that synaptic density network degeneration in ALS may follow a bottom-up transmission pattern, primarily involving in the medulla oblongata-striatum-neocortex network, which have the potential to capture new network-based targets for clinical therapy in the progression of ALS.
Authors
- Mian Hou
- Yongxiang Tang (ORCID: https://orcid.org/0000-0003-3987-8702)
- Shuo Hu (ORCID: https://orcid.org/0000-0003-0998-8943)
- Xuyang Wang (ORCID: https://orcid.org/0000-0001-6942-7289)
- Huafu Chen (ORCID: https://orcid.org/0000-0002-4062-4753)
- Ting Zou (ORCID: https://orcid.org/0000-0003-1747-1426)
- Rong Li (ORCID: https://orcid.org/0000-0001-7266-0241)
- Honghao Han
Institutions
- Central South University (CN)
- University of Electronic Science and Technology of China (CN)
- University Hospital of Bern (CH)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2025.103814
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00