Inhibiting the REV-ERBα expression protects against mechanical overloading-induced cartilage clock disruption and osteoarthritis progression
Inhibition REV-ERBα expression by clock-based therapeutic drug SR8278 or MAPK-MYC pathway inhibitors could ameliorate mechanical overloading-induced circadian disruption of cartilage and OA degeneration, indicating a clinical conversion potential for OA treatment.
Authors
- Hailun Xu (ORCID: https://orcid.org/0009-0000-1289-2892)
- Bowei Ni
- Guangyu Ding
- Qing‐Jun Meng (ORCID: https://orcid.org/0000-0002-9426-8336)
- Yuejiao Zhang
- Ting He (ORCID: https://orcid.org/0009-0003-0594-4190)
- Xinyu Zhang
- Liu Yang (ORCID: https://orcid.org/0000-0002-6498-4702)
- Xiaojie Xu (ORCID: https://orcid.org/0000-0002-8478-9728)
- Zixiang Wu (ORCID: https://orcid.org/0000-0002-6164-5019)
- Xue Hao
- Dong Wang (ORCID: https://orcid.org/0000-0003-4415-1102)
Institutions
- Northwestern Polytechnical University (CN)
- University of Manchester (GB)
- Northwest University (CN)
- Shanghai Stomatological Hospital (CN)
- Xi'an Honghui Hospital (CN)
- Xijing Hospital (CN)
- Xi'an Jiaotong University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.jot.2025.06.005
- Citations
- 3
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 2.74