Effect of dapagliflozin on sepsis-induced kidney injury in a rat model: modulation of the NLRP3 pathway
Prophylactic DPG administration exerts notable renoprotective effects in sepsis-induced AKI by mitigating inflammation, oxidative stress, and apoptosis. These findings highlight its potential as a preventive strategy, warranting further investigation in therapeutic contexts.
Authors
- Nasıf Fatih Karakuyu (ORCID: https://orcid.org/0000-0002-2249-4668)
- Halil Aşçı (ORCID: https://orcid.org/0000-0002-1545-035X)
- Adem Milletsever (ORCID: https://orcid.org/0000-0002-3614-7798)
- Pınar Karabacak (ORCID: https://orcid.org/0000-0002-6210-5962)
- İlter İlhan (ORCID: https://orcid.org/0000-0003-3739-9580)
- Gülsüm Özge Doğanavşargil Baysal
- Öznur Kolay (ORCID: https://orcid.org/0009-0002-3768-7996)
Institutions
- Süleyman Demirel Üniversitesi (TR)
- Suleyman Demirel University (KZ)
- Burdur Mehmet Akif Ersoy Üniversitesi (TR)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1080/08923973.2025.2519597
- Citations
- 3
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 4.29