Determinants of Submaximal Exercise Intolerance in Patients with Heart Failure and Preserved Ejection Fraction: Insights from the Lactate Threshold
Two-thirds of patients with HFpEF reach LT at workloads typical of activities of daily living. Patients with HFpEF and impaired submaximal fitness are more likely to be female, have greater pulmonary vascular disease and anaemia severity, and display greater haemodynamic, symptomatic, and ventilatory control abnormalities during low-level exercise, which are not apparent at maximal exertion. These findings have therapeutic implications and suggest a potentially important role for wider evaluation of submaximal fitness in addition to peak aerobic capacity.
Authors
- Tatsuro Ibe (ORCID: https://orcid.org/0000-0002-8162-4004)
- Shunichi Doi (ORCID: https://orcid.org/0000-0002-9224-4138)
- Jwan A. Naser (ORCID: https://orcid.org/0000-0002-6210-7669)
- Barry A. Borlaug (ORCID: https://orcid.org/0000-0001-9375-0596)
- Yogesh N.V. Reddy (ORCID: https://orcid.org/0000-0001-5322-0902)
- Joshua R. Smith (ORCID: https://orcid.org/0000-0002-3687-6261)
- Tomonari Harada (ORCID: https://orcid.org/0000-0003-4662-2991)
- Atsushi Tada (ORCID: https://orcid.org/0009-0000-7998-1881)
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1002/ejhf.3729
- Citations
- 2
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 4.76
Funders
- U.S. Department of Defense
- Japan Research Foundation for Clinical Pharmacology
- National Heart, Lung, and Blood Institute
- Congressionally Directed Medical Research Programs