Clinicopathological significance of identifying glypican 3 -positive gastric cancer

GPC3 is expressed in some cases of gastric adenocarcinoma, particularly in cancers with elevated serum AFP levels, providing a potential basis for clinical monitoring and exploring new immunotherapy targets. GPC3-GC often exhibits strong invasive and metastatic capabilities and may carry a poor prognosis, especially in cases with enteroblastic differentiation and elevated serum AFP. Therefore, it is crucial to enhance awareness and differentiate GPC3-GC from common adenocarcinoma.