Genomic profiling of primary tumor and lymph node metastasis in patients with clinically node-positive breast cancer: prospective cohort study within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57–18, ABCSG-53, GBG 101)
Disagreement in genomically estimated risk exists in over 15 % of patients, potentially leading to over- or undertreatment. Consequently, the applicability of genomic tests in LNm remains controversial.
Authors
- Michael Knauer (ORCID: https://orcid.org/0000-0002-6266-9194)
- Christoph Tausch
- Vesna Bjelic‐Radisic (ORCID: https://orcid.org/0000-0002-3749-4775)
- Susanne Bucher
- Valerijus Ostapenko (ORCID: https://orcid.org/0000-0001-8930-311X)
- Inga Bekes
- William Audeh (ORCID: https://orcid.org/0000-0002-7790-7466)
- Andrea Menicucci
- Ákos Sávolt
- Daniel Egle (ORCID: https://orcid.org/0000-0003-0283-8176)
- Stefanie Hayoz (ORCID: https://orcid.org/0000-0002-2265-6559)
- Simone E. Muenst (ORCID: https://orcid.org/0000-0001-7973-1401)
- Martin Heidinger
- Rok Satler
- Colin Simonson (ORCID: https://orcid.org/0000-0003-2041-8765)
- William P. Weber (ORCID: https://orcid.org/0000-0003-1667-7844)
- Christian Kurzeder (ORCID: https://orcid.org/0000-0003-4368-7490)
- Giang Thanh Lam
- Jörg Heil
Institutions
- Witten/Herdecke University (DE)
- University of Lucerne (CH)
- University of Basel (CH)
- University of St.Gallen (CH)
- University Hospital of Basel (CH)
- Kantonsspital Winterthur (CH)
- University Hospital of Geneva (CH)
- National Institute of Oncology (HU)
- Breast Center (CH)
- OST - Ostschweizer Fachhochschule (CH)
- Agendia (Netherlands) (NL)
- Swiss Group For Clinical Cancer Research (CH)
- National Cancer Institute (LT)
- Austrian Breast & Colorectal Cancer Study Group (AT)
- Hôpital du Valais (CH)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.ejca.2025.115585
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00