Hippocampus and amygdala volume and morphology in neurodegenerative disorders with co-morbid epilepsy
We identified hippocampal body and tail atrophy in AD + Epi and right hippocampal head, tail, and amygdalar atrophy in nonAD + Epi. Different lateralized and region-specific patterns of limbic atrophy and dysmorphia highlight potential differences in the pathophysiology and the possible role of epilepsy in altering the trajectory of neurodegeneration in AD and nonAD.
Authors
- P. Thomas Fletcher (ORCID: https://orcid.org/0000-0002-3111-2553)
- Ifrah Zawar (ORCID: https://orcid.org/0000-0002-6103-4250)
- Mark Quigg (ORCID: https://orcid.org/0000-0003-3035-9260)
- Carol A. Manning (ORCID: https://orcid.org/0000-0003-4205-2485)
- Jaideep Kapur (ORCID: https://orcid.org/0000-0002-8608-1352)
- Shen Zhu
Institutions
- University of Virginia (US)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2025.103830
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00