Trends in Surgical Treatment for cT4 Breast Cancer After Neoadjuvant Systemic Therapy: A Nationwide Study in The Netherlands
Modified radical mastectomy rates decreased over time. De-escalated surgery was associated with improved 5-year overall survival compared with MRM. These findings suggest that de-escalated surgery is at least equivalent to MRM in terms of survival and may support consideration of less invasive surgical approaches.
Authors
- Thomas Borchert
- Marissa C. van Maaren (ORCID: https://orcid.org/0000-0002-5708-2559)
- Sabine Siesling
- Emily L. Postma (ORCID: https://orcid.org/0000-0001-8460-0553)
- Britt A M Jansen (ORCID: https://orcid.org/0000-0002-7533-4932)
- Annemiek Doeksen
- Johannes C. Kelder (ORCID: https://orcid.org/0000-0002-8143-5078)
- Femke van der Leij
- Carolien P. Schröder
- Dominique J P van Uden
Institutions
- University Medical Center Groningen (NL)
- University Medical Center Utrecht (NL)
- St. Antonius Ziekenhuis (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Netherlands Comprehensive Cancer Organisation (NL)
- University of Twente (NL)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1245/s10434-025-17585-2
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00