Delivery of crocetin by grafting onto the surface of poly-aminopropylmethyl-silsesquioxane: Biocompatibility and wound healing ability assessment

poly-aminopropylmethyl-silsesquioxane (PAMSQ) has been prepared and it was used to graft crocetin. PAMSQ was characterized by UV–Vis, FT-IR, and SEM-EDS analyses, which confirmed the successful grafting of crocetin onto the surface of PAMSQ. Blood compatibility and MTT assay on the 3 T3 cell line confirmed the biocompatibility of this product. Therefore, the effect of the prepared sample was investigated on healing the 1.50 × 1.50 cm 2 induced wound in rats. The results of H&E and MT staining established acceptable effect of this sample on lowering the healing period by increasing the rate of collagen production. • Crocetin was grafted covalently onto the surface of poly-aminopropyl-silsesquioxane. • The blood compatibility of the product was investigated in-vitro. • The cytotoxicity of the product was investigated toward 3 T3 cells line in-vitro. • The product was used in-vivo for wound healing in rats.