Management of paediatric ulcerative colitis, part 2: Acute severe colitis—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organizati

Acute severe colitis (ASC) is a relatively frequent manifestation in children with ulcerative colitis and one of the few emergencies in paediatric gastroenterology. A standardized proactive approach based on tight monitoring and timely medical and surgical interventions may improve patients' outcomes. We aimed to update the previous ASC guidelines using detailed recommendations and practice points, based on a systematic review of the literature and consensus of experts. These guidelines update is a joint effort of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organization. A systematic search was performed in Pubmed Ovid Medline, Embase and Cochrane databases using 13 predefined PICO (patient, intervention, comparison, outcomes) based questions and 30 non-PICO based questions. Grading methodology was based on the Oxford Centre for Evidence-Based Medicine-Levels of evidence. The questions were addressed by working subgroups following an iterative consensus voting process, including three online voting meetings and one face-to-face meeting. A total of 36 recommendations and 72 practice points were endorsed with a consensus rate of at least 88% for all statements, regarding initial evaluation, monitoring, medical and surgical treatment of ASC in children. Several topics have been revised since the previous 2018 guidelines and differ from corresponding published adult guidelines. These guidelines present a comprehensive overview of the management of ASC in children, offering practical recommendations and practice points aiming to standardize clinical and surgical treatment and improve outcomes of this severe scenario.

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Publication Details

Journal
Journal of Pediatric Gastroenterology and Nutrition
Published
2025-06-17
DOI
https://doi.org/10.1002/jpn3.70096
Citations
8
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
12.72

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article

Management of paediatric ulcerative colitis, part 2: Acute severe colitis—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organizati

Ola Olén, Marco Gasparetto, Hannah Gordon, Amit Assa et al.
8 citations
Journal of Pediatric Gastroenterology and Nutrition
Inflammatory Bowel Disease
12.72
article

Management of paediatric ulcerative colitis, part 2: Acute severe colitis—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organizati

Ola Olén, Marco Gasparetto, Hannah Gordon, Amit Assa, Gianluca Pellino, Marina Aloi, Iva Hojsak, Séamus Hussey, Stéphanie Van Biervliet, Johan Van Limbergen, Laura Gianolio, Alexandra Hudson, Jiří Bronský, Erasmo Miele, Lorenzo Norsa, Richard Kay Russell, Anat Yerushalmy‐Feler, Lissy de Ridder, David C. Wilson, Eytan Wine, Dan Turner, Javier Martín de Carpi, Eunice Trindade, Dror S. Shouval, Patrick van Rheenen
article en
8 citations

Abstract

Acute severe colitis (ASC) is a relatively frequent manifestation in children with ulcerative colitis and one of the few emergencies in paediatric gastroenterology. A standardized proactive approach based on tight monitoring and timely medical and surgical interventions may improve patients' outcomes. We aimed to update the previous ASC guidelines using detailed recommendations and practice points, based on a systematic review of the literature and consensus of experts. These guidelines update is a joint effort of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organization. A systematic search was performed in Pubmed Ovid Medline, Embase and Cochrane databases using 13 predefined PICO (patient, intervention, comparison, outcomes) based questions and 30 non-PICO based questions. Grading methodology was based on the Oxford Centre for Evidence-Based Medicine-Levels of evidence. The questions were addressed by working subgroups following an iterative consensus voting process, including three online voting meetings and one face-to-face meeting. A total of 36 recommendations and 72 practice points were endorsed with a consensus rate of at least 88% for all statements, regarding initial evaluation, monitoring, medical and surgical treatment of ASC in children. Several topics have been revised since the previous 2018 guidelines and differ from corresponding published adult guidelines. These guidelines present a comprehensive overview of the management of ASC in children, offering practical recommendations and practice points aiming to standardize clinical and surgical treatment and improve outcomes of this severe scenario.

Journal of Pediatric Gastroenterology and NutritionVol. 81(3)
University College Dublin (IE), University of East Anglia (GB), Universitat Autònoma de Barcelona (ES), Hospital Sant Joan de Déu Barcelona (ES), University Medical Center Groningen (NL), University of Alberta (CA), Tel Aviv University (IL), University of Groningen (NL), University of Zagreb (HR), University of Toronto (CA), University of Milan (IT), University of Campania "Luigi Vanvitelli" (IT), Norfolk and Norwich University Hospital (GB), Tel Aviv Sourasky Medical Center (IL), Norfolk and Norwich University Hospitals NHS Foundation Trust (GB), Royal Hospital for Children (GB), Ghent University Hospital (BE), Hospital for Sick Children (CA), Shaare Zedek Medical Center (IL), John Radcliffe Hospital (GB), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Karolinska Institutet (SE), Children's Health Ireland at Crumlin (IE), Hospital de São João (PT), Emma Kinderziekenhuis (NL), University Hospital in Motol (CZ), Schneider Children's Medical Center (IL), Federico II University Hospital (IT), Children's Hospital Zagreb (HR), Erasmus MC - Sophia Children’s Hospital (NL), Oxford University Hospitals NHS Trust (GB), Centre for Inflammation Research (GB), Amsterdam University Medical Centers (NL), University of Naples Federico II (IT), University of Edinburgh (GB)
Pfizer
Zero hunger
Openalex Percentile: Top 1%
Inflammatory Bowel Disease
12.72
DOIOpen Access PDFOpenAlex
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