Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation
These findings suggest early initiation of ART reduces the production of anti-Tat antibodies and reduces CD8+ T-cell activation. Further studies on the impact of early ART on antiviral immune responses are needed and may shed light on mechanisms of optimal immune reconstitution and reservoir control in PLWH.
Authors
- Kavidha Reddy (ORCID: https://orcid.org/0000-0002-7024-0574)
- Nompumelelo P. Mkhwanazi (ORCID: https://orcid.org/0000-0002-0808-9201)
- Thumbi Ndung’u (ORCID: https://orcid.org/0000-0003-2962-3992)
- Thandeka Innocentia Kubheka
- Kewreshini K. Naidoo
Institutions
- Ragon Institute of MGH, MIT and Harvard (US)
- Africa Health Research Institute (ZA)
- Institute of Infection and Immunity (CA)
- University College London (GB)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1564960
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- European Commission
- National Research Foundation