IL-24 producing regulatory T and B lymphocytes in endometriosis
We have shown, for the first time, that Tregs and Bregs secrete IL-24 and that their percentages are altered in endometriosis. The significance of this cytokine secretion by regulatory cells is unclear, but we speculated that IL-24 may enhance the improper immunosuppressive activity of Tregs and plasmablasts in endometriosis, which enables the implantation and growth of endometrial lesions outside the uterus.
Authors
- Anna Chełmońska‐Soyta (ORCID: https://orcid.org/0000-0001-7360-3257)
- Anna Kalota (ORCID: https://orcid.org/0009-0002-4257-3344)
- A Kedzierska (ORCID: https://orcid.org/0000-0002-0804-2710)
- Anna Sławek (ORCID: https://orcid.org/0000-0002-5103-138X)
- Agnieszka Chrobak (ORCID: https://orcid.org/0000-0003-3404-7029)
- Krzysztof Grzymajło
- J Pajak
- Daria Lorek (ORCID: https://orcid.org/0000-0002-3761-3877)
- Mikolaj Karmowski
Institutions
- University of Life Sciences in Lublin (PL)
- Medical University of Silesia (PL)
- Medical University of Warsaw (PL)
- Wrocław University of Environmental and Life Sciences (PL)
- Endometriosis UK (GB)
- 1 Military Clinical Hospital with Outpatient Clinic (PL)
- Euromedic (PL)
- Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (PL)
- AGH University of Krakow (PL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1582762
- Citations
- 2
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.40