Immunopathological features of highly pathogenic Korean Lineage B PRRSV-2: insights into virulence indicators and host immune responses
These results highlight the differential virulence and immunomodulatory profiles of genetically distinct PRRSV-2 strains circulating in Korea. The heightened immune checkpoint expression, particularly in PJ10-infected pigs, underscores a potential mechanism of PRRSV-induced immune suppression and viral persistence. This study provides critical insights into PRRSV pathogenesis and host-virus interactions and supports the need for lineage-adapted control strategies that account for both the genetic heterogeneity of PRRSV and immune evasion mechanisms.
Authors
- Hwan-Ju Kim (ORCID: https://orcid.org/0000-0001-5524-4908)
- Gyeong-Seo Park (ORCID: https://orcid.org/0000-0002-2586-2307)
- Go-Eun Shin (ORCID: https://orcid.org/0000-0001-6619-1258)
- Kyoung-Ki Lee (ORCID: https://orcid.org/0000-0002-6832-6264)
- Won‐Il Kim (ORCID: https://orcid.org/0000-0002-0465-0794)
- Seung-Chai Kim (ORCID: https://orcid.org/0000-0002-1152-2248)
- Chang‐Gi Jeong (ORCID: https://orcid.org/0000-0002-0186-9248)
- Sang Chul Kang (ORCID: https://orcid.org/0000-0003-2845-981X)
- Sang‐Myeong Lee (ORCID: https://orcid.org/0000-0002-3624-3392)
- Seoung-Hee Kim
- Hye-Young Jeong
Institutions
- International Vaccine Institute (KR)
- Chungbuk National University (KR)
- Komipharm International (South Korea) (KR)
- Animal and Plant Quarantine Agency (KR)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1599468
- Citations
- 2
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.39