Complete recovery after complement factor I deficiency associated fulminant acute hemorrhagic leukoencephalitis: a case report
As AHLE is an emerging phenotype of complement FI deficiency, with only a few previously reported cases in the literature, high clinical suspicion and awareness among clinicians are needed. To control the complement system, prompt blockade with complement FI substitution via PEX and early decompressive craniectomy may be life-saving. In neuroinflammatory diseases with unknown etiology, complement testing is recommended.
Authors
- Zoltán Prohászka (ORCID: https://orcid.org/0000-0003-1761-7982)
- Zoltán Liptai (ORCID: https://orcid.org/0000-0002-1309-3248)
- Gábor Szarvas (ORCID: https://orcid.org/0000-0002-8640-9688)
- Ágnes Szilágyi (ORCID: https://orcid.org/0000-0002-9769-3215)
- Péter Barsi (ORCID: https://orcid.org/0000-0002-3574-9973)
- Ádám Goschler
- Simon Péter Nagy (ORCID: https://orcid.org/0000-0001-7196-768X)
- Sarolta Dobner (ORCID: https://orcid.org/0000-0002-7768-7803)
- Tímea Seszták
- E Varga
- Klára Horváth (ORCID: https://orcid.org/0000-0002-8198-9345)
- L Szabó (ORCID: https://orcid.org/0000-0003-2621-1378)
- Fanni Szumutku
Institutions
- Semmelweis University (HU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1586288
- Primary Topic
- Infectious Encephalopathies and Encephalitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00