Evolving fitness and immune escape: a retrospective analysis of SARS-CoV-2 spike protein (2020-2024) using protein language model
CoVFit offers key insights into SARS-CoV-2 evolution, aiding vaccine design. Persistent viral adaptation despite interventions highlights the need for surveillance and adaptive strategies using tools like CoVFit for preparedness.
Authors
- Leke Lyu (ORCID: https://orcid.org/0009-0004-5657-8271)
- Justin Bahl (ORCID: https://orcid.org/0000-0001-7572-4300)
- M. H. M. Mubassir (ORCID: https://orcid.org/0000-0002-9674-2425)
- Sihua Peng (ORCID: https://orcid.org/0000-0001-7231-666X)
- Sachin Subedi (ORCID: https://orcid.org/0000-0002-1145-8880)
- Ludy Registre Carmola
- Mohamed A Bakheet
Institutions
- University of Georgia (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1576414
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- U.S. Department of Health and Human Services
- Centers for Disease Control and Prevention