ER stress genes (COL1A1, LOXL2, VWF) predicts IKK-16 as a Candidate therapeutic target for colitis-related inflammation and fibrosis suppression
These results suggest that ERS-related genes, particularly COL1A1, LOXL2, and VWF, may regulate UC fibrosis through interactions with immune cells. IKK-16 shows promise as a therapeutic agent. These findings provide new insights into UC pathogenesis and potential clinical treatment strategies.
Authors
- Qingqing Yang (ORCID: https://orcid.org/0000-0002-0807-0551)
- Jun‐Meng Wang (ORCID: https://orcid.org/0000-0003-3771-4026)
- Yuemei Wang (ORCID: https://orcid.org/0000-0002-7975-1856)
- Qianhui Huang (ORCID: https://orcid.org/0000-0002-3292-7519)
- Jianping Guo (ORCID: https://orcid.org/0000-0002-5031-3510)
- Yang Jiao
- Chengshuai Cui (ORCID: https://orcid.org/0009-0006-6495-0808)
- Ke Zhang (ORCID: https://orcid.org/0000-0002-6527-3427)
- Qiao‐Feng Wu (ORCID: https://orcid.org/0000-0002-8870-6707)
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1587860
- Citations
- 3
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China