In evolution’s unending race: ancestral STING sensors in Salmo salar mediate intracellular bacterial detection and programmed cell death through evolutionarily conserved pathways
This study positions <i>S. salar</i> as a high-resolution model for STING biology and introduces the Evolutionary Molecular Immunity Race (EMIR) framework, where STING orchestrates immune fate across hundreds of millions of years of vertebrate evolution, and over the last ~80 million years within the salmonid lineage.
Authors
- Adolfo Isla (ORCID: https://orcid.org/0000-0003-2168-4029)
- Marcos Mancilla (ORCID: https://orcid.org/0000-0003-0100-2190)
- Patricio Bustos (ORCID: https://orcid.org/0000-0003-4761-2576)
- Claudia A. Barrientos
- Alejandro J. Yáñez (ORCID: https://orcid.org/0000-0002-4619-4600)
- Yassef Yuivar
- Francisco T Yañez
- Jorge F. Beltrán (ORCID: https://orcid.org/0000-0002-2823-1981)
- Felipe Almendras (ORCID: https://orcid.org/0000-0002-3163-786X)
- Sandra N. Flores-Martin
- Adriana Ojeda
- Genaro Soto-Rauch
- Marcelo N. Aguilar
Institutions
- Universidad de La Frontera (CL)
- Austral University of Chile (CL)
- Centro de Investigación y Desarrollo (ES)
- Millennium Nucleus of Ion Channel Associated Diseases (CL)
- Universidad Santo Tomás (CL)
- Interdisciplinary Center for Aquaculture Research (CL)
- University of Chile (CL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1570871
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Austral de Chile
- Agencia Nacional de Investigación y Desarrollo
- Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica
- Fondo Nacional de Desarrollo Científico y Tecnológico
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias