Short-term high-fat diet feeding plus acute ethanol binge induced acute liver injury in mice via oxidative stress, inflammation and pyroptosis
Short-term HFD feeding plus a single dose of ethanol gavage can significantly exacerbate acute liver injury and hepatic fat deposition in mice by enhancing oxidative stress, MAPK and NF-κB signaling, and Caspase-1/8/11-GSDMD and Caspase-3-GSDME pyroptosis signaling.
Authors
- Xinling Chen (ORCID: https://orcid.org/0000-0002-8442-0592)
- Yaxing Zhang (ORCID: https://orcid.org/0000-0002-1179-8076)
- Jiean Xu (ORCID: https://orcid.org/0000-0001-9176-5786)
- Luyao Xu (ORCID: https://orcid.org/0000-0002-2757-5782)
- Jiaying Dai
- Qiuling Li
- Min Dai (ORCID: https://orcid.org/0000-0002-1681-6990)
- Jin-Wen Xu (ORCID: https://orcid.org/0000-0002-6588-1350)
- Chen Lu (ORCID: https://orcid.org/0000-0002-7781-696X)
- Kangrong Wang
- Yao Deng (ORCID: https://orcid.org/0000-0002-0602-1457)
- Zaoyuan Kuang
- Wenhai Guo (ORCID: https://orcid.org/0000-0002-3426-6013)
- Yun Chen (ORCID: https://orcid.org/0000-0001-9831-0215)
- Wei Liu (ORCID: https://orcid.org/0000-0002-5925-3059)
- Hao‐Jie Zhu (ORCID: https://orcid.org/0000-0002-2248-4419)
- Wenting Suo
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fphar.2025.1602280
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangdong Province
- Guangdong Medical Research Foundation