The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis
This study identifies distinct and shared signaling pathways in PR3-AAV and MPO-AAV, highlighting STAT3 and TNF pathways as potential subtype-specific mechanisms. These findings offer insight into AAV pathogenesis and may guide the development of more targeted, less toxic treatments tailored to AAV subtypes.
Authors
- Ann Knight
- Vincent van Hoef (ORCID: https://orcid.org/0000-0003-1707-7066)
- Sophie Ohlsson (ORCID: https://orcid.org/0000-0002-5253-1650)
- Erik Hellbacher (ORCID: https://orcid.org/0000-0002-8151-3988)
- Per Eriksson (ORCID: https://orcid.org/0000-0002-5635-2692)
- Iva Gunnarsson (ORCID: https://orcid.org/0000-0002-4514-7706)
- Solbritt Rantapää‐Dahlqvist (ORCID: https://orcid.org/0000-0001-8259-3863)
- Alina Johansson
- Johanna Dahlqvist (ORCID: https://orcid.org/0000-0002-6283-644X)
- Annette Bruchfeld
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
- Skåne University Hospital (SE)
- Umeå University (SE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1600754
- Citations
- 1
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Svenska Sällskapet för Medicinsk Forskning
- Akademiska Sjukhuset
- Uppsala Universitet
- Agnes och Mac Rudbergs Stiftelse
- Svenska Läkaresällskapet
- Stiftelsen Konung Gustaf V:s 80-årsfond
- Reumatikerförbundet
- Njurfonden
- Science for Life Laboratory