Chorionic Villus Sampling for Rapid Confirmation of High‐Risk NIPT Results for Trisomy 21, 18, and 13
A definitive diagnosis of CVS was achieved in 97.5%, 100%, and 86.5% of patients with high-risk NIPT results for trisomy 21, 18, and 13, respectively. Moreover, our clinical practice confirms that the majority of pregnant women (70%) opted for CVS as a quick confirmatory test. We conclude that both CVS and AC can be offered when preceded by pre-test counseling on the risks of potential inconclusive results as calculated in this study.
Authors
- Krista Prinsen
- Vyne van der Schoot (ORCID: https://orcid.org/0000-0001-9829-9220)
- Anneke Dijkman
- Robert‐Jan H. Galjaard (ORCID: https://orcid.org/0000-0002-8101-6180)
- Karin E. M. Diderich (ORCID: https://orcid.org/0000-0003-2637-9998)
- Myrthe van den Born
- Malgorzata I. Srebniak (ORCID: https://orcid.org/0000-0003-3429-6156)
- Maarten F. C. M. Knapen (ORCID: https://orcid.org/0000-0001-8869-9554)
- Attie T. J. I. Go (ORCID: https://orcid.org/0000-0002-9206-5279)
- Philip DeKoninck (ORCID: https://orcid.org/0000-0002-4457-0940)
- Sabina de Weerd
- Mark Drost
- Jérôme Cornette (ORCID: https://orcid.org/0000-0001-8482-5138)
- Diane Van Opstal (ORCID: https://orcid.org/0000-0002-3895-6775)
- Dimitri Papatsonis
- Marieke Joosten
- Julia J. Spaan
- Marjolein J.A. Weerts
Institutions
- Erasmus MC (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Reinier de Graaf Hospital (NL)
- Amphia Ziekenhuis (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Prenatal Diagnosis
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1002/pd.6837
- Citations
- 1
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.49