Natural product library screening identifies Darutigenol for the treatment of myocardial infarction and ischemia/reperfusion injury
Our data revealed that the small molecule compound Dar, screened from the natural product library in this study, is capable of protecting heart against MI and I/R injury by activating AKT1 pathway. These findings enrich the natural product candidates for cardiovascular disease treatment and provide new insights into potential therapeutic agents for MI and I/R injury.
Authors
- Xufeng Qi (ORCID: https://orcid.org/0000-0002-5911-071X)
- Hao Wang (ORCID: https://orcid.org/0000-0003-2169-1712)
- Hongji Li (ORCID: https://orcid.org/0000-0002-9783-6845)
- Zipeng Ye (ORCID: https://orcid.org/0000-0002-1605-4527)
- Li Zheng (ORCID: https://orcid.org/0000-0002-6790-8940)
- Hui Zhao (ORCID: https://orcid.org/0000-0001-8160-6415)
- Kun Liu (ORCID: https://orcid.org/0000-0003-3512-4516)
- Cheng Li (ORCID: https://orcid.org/0000-0002-0449-3709)
- Meng Wang (ORCID: https://orcid.org/0000-0002-1727-1187)
- Qian-Yu Huang
Institutions
- Guangdong University of Technology (CN)
- Jinan University (CN)
- Chinese University of Hong Kong (HK)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Regenerative Medicine Institute (MX)
- Guangdong Provincial People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1186/s13020-025-01141-x
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Special Fund for Agro-scientific Research in the Public Interest
- Fundamental Research Funds for the Central Universities
- Key Laboratory of Trustworthy Distributed Computing and Service of Ministry of Education
- Fundamental and Frontier Research Project of Chongqing