Exosomal FOXL1 from bone marrow mesenchymal stem cells activates the METTL3/ATXN2L pathway to ameliorate high glucose-induced human retinal microvascular endothelial cell injury
Exosomal FOXL1 from BMSCs stabilized METTL3 to increase ATXN2L expression, thus offering a protective effect against high glucose-induced injury in HRMECs. This finding holds clinical significance for the development of targeted therapies for DR.
Authors
- Daoquan Dong
- Ying-li Dong
- Longjiang Cui
- C. NIU (ORCID: https://orcid.org/0000-0003-0727-5763)
- Wei Wang (ORCID: https://orcid.org/0000-0001-7845-6479)
Institutions
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1186/s13098-025-01804-7
- Citations
- 5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.03