Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant prostate cancer
A novel nanovaccines induces potent antitumor immune responses and, in combination with the chemotherapeutic agent cisplatin, effectively remodels the tumor immune microenvironment. This approach offers a new strategy and preclinical evidence for the immunotherapy of "cold tumors" prostate cancer.
Authors
- Rui Zhao (ORCID: https://orcid.org/0000-0001-8794-8299)
- Shimiao Zhu
- Zhongqiang Fan
- Hui Zhang (ORCID: https://orcid.org/0000-0003-4366-4002)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-0840-0995)
- Zhao Wang (ORCID: https://orcid.org/0000-0002-6820-7505)
- Xiaoqiang Liu
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1007/s00262-025-04070-8
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China