Association of DNA methylation epigenetic markers with all-cause mortality and cardiovascular disease-related mortality in diabetic population: a machine learning-based retrospective cohort study
We found four DNAm-derived epigenetic markers (ZhangAge, GrimAge2 Mort, TIMP1Mort, PhenoAge) that are associated with all-cause mortality risk in the diabetic population. Further research suggested that GrimAge and PhenoAge influence the risk of cardiovascular-related mortality.
Authors
- Qian Sun (ORCID: https://orcid.org/0000-0002-4878-3599)
- Xinyu Zhou (ORCID: https://orcid.org/0000-0003-1908-0357)
- Yafeng Zhou (ORCID: https://orcid.org/0009-0005-2606-3776)
- Huimin Fan (ORCID: https://orcid.org/0009-0004-5530-974X)
- Pinfang Kang (ORCID: https://orcid.org/0000-0001-7084-7862)
- Yufeng Jiang
- Huazhen Huang (ORCID: https://orcid.org/0009-0007-6841-505X)
- Anchen Xu (ORCID: https://orcid.org/0000-0001-5033-8518)
- Yuxin Nong (ORCID: https://orcid.org/0000-0001-8217-2460)
- Hezi Jiang
- Xiangyu Wang (ORCID: https://orcid.org/0000-0002-1832-0905)
- Xian Li (ORCID: https://orcid.org/0000-0003-2948-7660)
- Xin Tan (ORCID: https://orcid.org/0009-0005-9741-6946)
- Shuai Xu (ORCID: https://orcid.org/0000-0001-7919-2874)
- Hongju Wang (ORCID: https://orcid.org/0000-0002-1662-485X)
- Lulu Xu (ORCID: https://orcid.org/0000-0003-1082-1067)
- Jili Fan
- Yiyao Zeng
- Xiaohong Bo
Institutions
- Bengbu Medical College (CN)
- Chinese Academy of Sciences (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1186/s13098-025-01774-w
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Natural Science Research of Jiangsu Higher Education Institutions of China