Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8 <sup>+</sup> T Cell Clones
Our findings support the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8<sup>+</sup> T cell clonality and that specific T cells migrate between these compartments to propagate inflammation across both sites.
Authors
- Frances Humby (ORCID: https://orcid.org/0000-0003-1280-9133)
- Lucy E. Durham (ORCID: https://orcid.org/0000-0002-6726-9245)
- Pawan Dhami (ORCID: https://orcid.org/0000-0002-5408-1833)
- Leonie S. Taams (ORCID: https://orcid.org/0000-0002-9337-7194)
- Rosamond Nuamah
- Rosie Ross (ORCID: https://orcid.org/0009-0008-8248-0752)
- Kathy Fung
- Giovanni A. M. Povoleri (ORCID: https://orcid.org/0000-0003-0342-651X)
- Bruce Kirkham (ORCID: https://orcid.org/0000-0002-5110-3320)
- Roman Laddach (ORCID: https://orcid.org/0000-0002-0118-4548)
- Kathryn J. A. Steel (ORCID: https://orcid.org/0000-0002-4446-0506)
- Athul Menon Kallayil
- Sarah Ryan (ORCID: https://orcid.org/0000-0002-0650-3069)
- Elizabeth H. Gray
- Nora Ng
Institutions
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Thomas Foundation (AU)
- Centre for Inflammation Research (GB)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1002/art.43286
- Citations
- 9
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 7.18
Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Cancer Research UK
- National Institute for Health and Care Research
- King's Health Partners
- Versus Arthritis
- Foundation for Research in Rheumatology
- Medical Research Council
- Menzies Centre for Australian Studies, King's College London, University of London
- NIHR Sheffield Biomedical Research Centre