In knee osteoarthritis, the production of cytokines and metalloproteinases in presence of chondrocytes and CD4+ T cells depends on T cell subset: An in vitro analysis
This study indicates that chondrocytes can interact with CD4<sup>+</sup> T cell subsets in OA, modulating the production of metalloproteinases and cytokines to varying degrees, depending on the CD4<sup>+</sup> T cell subset. Our findings can open new avenues in OA treatment using T cell-based or T cell subset-targeted therapies to modulate inflammatory patterns in affected OA joints.
Authors
- Babak Moradi (ORCID: https://orcid.org/0000-0003-2743-6819)
- Simone Gantz
- Maciej J. K. Simon (ORCID: https://orcid.org/0000-0001-7288-9388)
- Hadrian Platzer (ORCID: https://orcid.org/0000-0001-9805-3810)
- Ghazal Pourbozorg
- Ravikumar Mayakrishnan
- Malte Wellbrock
- B Khamees
Institutions
- Hochschule für Angewandte Wissenschaften Kiel (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Schleswig-Holstein (DE)
- Clinical Research Center Kiel (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100642
- Citations
- 4
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Deutschen Arthrose-Hilfe
- Deutsche Forschungsgemeinschaft